“This large cohort study provides new evidence of the significant health economic burden of cow’s milk allergy in children,” said lead study author Abbie L. Cawood, PhD, RN, MICR, Nutricia Ltd, Trowbridge Science operations manager, and her colleague writes.write in Clinical and Translational Allergy.
“Management of cow’s milk allergy requires the elimination of cow’s milk protein from the diet. Breast milk remains an ideal source of nutrition for infants with cow’s milk allergy; We need allergenic formulas.” Fellow, University of Southampton, and her co-author.
Mild cow allergy, an immune-mediated reaction to one or more proteins in cow’s milk, is one of the most common childhood food allergies, affecting 2% to 5% of infants in Europe. increase. Management includes avoiding cow’s milk proteins and treating gastrointestinal, skin, respiratory, and other allergic conditions that may be associated, the authors explain.
Cawood and her colleagues turned to The Health Improvement Network (THIN), Cegedim Rx’s proprietary database of 2.9 million anonymized active patient records, in a retrospective matched cohort study. They extracted data from approximately 7000 case records spanning five years (2015-2020).
They looked at drug prescriptions and health care professional contacts based on diagnostic read codes and hypoallergenic prescriptions, and compared health care costs for children with cow’s milk allergy to those without. .
They matched 3,499 children aged 1 year or younger with confirmed or suspected cow’s milk allergy to the same number of children without cow’s milk allergy. About half of the participants were boys, and the mean follow-up period was 4.2 years.
Children with cow’s milk allergy need more costly medical care
Researchers have found that:
Children with cow’s milk allergy (CMA) were prescribed significantly more drugs than children without CMA. In particular, prescriptions for anti-reflux medications increased by almost 500%.
Children with CMA required significantly more contact with health care providers and at higher rates than children without CMA.
CMA was associated with an additional potential medical cost of £1381.53 per person per year. Assuming a prevalence of 2.5% from her estimated CMA prevalence range of 2% to 5%, and extrapolating to the UK infant population, CMA would add him over £25.7m to annual healthcare costs nationwide. may have been
“Some conditions in infancy require the elimination of cow’s milk-based formulas and require extensively hydrolyzed formulas or amino acid formulas, or complete breast milk if desired or possible.” Kara E. Coffey, M.D., Ph.D., assistant professor of pediatrics at the University of Pittsburgh.Pennsylvania medical school said Medscape Medical News on mail.
“This study shows that regardless of the reason for milk-based avoidance, these infants require more access to health services (clinic visits, nutritional assessments, prescriptions). [do] This certainly puts a lot of time and money into ensuring their families have the ability to grow and thrive,” added Coffey, who was not involved in the study.
Jodi A. Shlova, MSN, APRN, CPNP, Food Allergy Program Coordinator at Children’s Mercy in Kansas City, Missouri, didn’t find these numbers surprising.
“Children with food allergies usually have other atopic comorbidities and require more visits to their primary care physician or specialist, as well as more prescriptions,” Shlova said in an email. rice field.
“An interesting statement is that British guidelines recommend the involvement of a nutritionist in children with cow’s milk allergy,” she noted. Therefore, the involvement of a nutritionist would be a great addition to care, but not all health care practices have access to those resources.
“The high rate of antibiotic use by children with cow’s milk allergy and the nearly 500% increase in anti-reflux prescriptions warrants additional research,” she added.
Nutricia Ltd funded this research. Cawood and one of his co-authors are employed by Nutricia Ltd and all other co-authors are his Nutricia employees or have other financial ties with Nutricia. One of her co-authors is employed by her Cegedim Rx, which Nutricia funded for this study. Shroba and Coffey report no conflicts of interest in this study.
clin trans allergyPublished online on August 26, 2022. full text