Androstenedione is one of the supplements that has been marketed to athletes for years to speed up muscle growth and testosterone levels, but it comes with some serious risks.
Also known as “andro” Diet supplement It was once touted to improve athletic performance by stimulating muscle growth and boosting testosterone levels. There is a possibility.
In October 2004, President George Bush signed the Anabolic Steroids Control Act, reclassifying androstenedione from supplements to anabolic steroids and making androstenedione and other steroid-based drugs controlled substances. They are now banned in sports.
This is because a small number of studies on androstenedione have shown that because androstenedione is converted in the body to the hormone testosterone and certain forms of estrogen, its use may increase the risk of serious health problems. Because the Food and Drug Administration came to believe.
Androstenedione over the counter supplement Although now banned, doctors can prescribe it for medical purposes.
According to a study recently published online in the journal moleculeYour doctor may offer androstenedione injections to prevent or treat certain chronic conditions.
Dangers of Androstenedione
but supplement Associated with many side effects.
according to mayo clinicLong-term use of androstenedione supplements by men can result in the development of female characteristics such as testicular atrophy, impotence, and breast enlargement.
Women who use these products may develop masculine characteristics such as male pattern baldness, deepening of the voice, increased facial hair, and an enlarged clitoris. severe bleeding, and blood clotAndrostenedione may also increase the risk of breast and endometrial cancer.
Among children and teens, androstenedione may expose you to the same hormonal effects, early onset of puberty, and premature cessation of growth as in adults.
Andro supplements are good for the heart and blood vessel Anyone who takes it increases their risk of heart attack and stroke, according to the Mayo Clinic.
Not only do these supplements cause unwanted side effects, they can also interact dangerously with many other medications.
according to drug bank, Concentrations of androstenedione are increased when combined with the head lice drug abamethapyr and decreased when combined with the heart drug amiodarone.
Other interactions include elevated androstenedione levels in the presence of the prostate cancer drug apalutamide, and decreased levels when combined with aprepitant, which is used to prevent chemotherapy-induced nausea.
The HIV drug atazanavir can increase levels of androstenedione, as can the erectile dysfunction drug Avanafil (Stendra).
Severe edema may occur when androstenedione is used with the asthma drug beclomethasone dipropionate. The same is true for the arthritis drug betamethasone.
Also, the ability to metabolize androstenedione medicine berotralstat is used. Belotralstat is used to prevent angioedema, a hereditary swelling of the face, according to Drug Bank.
“Andro products may appear to have short-term benefits, but science shows that these same properties pose real and significant health risks,” said the then-FDA commissioner. Dr. Mark McClellan said. Said When supplements were first banned.
“The products are advertised for athletes, but they can end up in the hands of impressive young people who believe these products will help them grow,” McClellan said. Anyone who consumes these products in sufficient quantities to enhance their performance or performance is at risk of serious long-term and potentially irreversible health effects.
For more information:
Marwa T. Badawy et al, Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of its Consumption, Metabolism, Health Effects, and Toxicity with Sex Difference, molecule (2021). DOI: 10.3390/molecule 26206210
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